a carcinogenesis bioassay of c.i. disperse yellow 3 (87.6 dye), a textile dye, was conducted by feeding diets containing 5,000 or 10, 000 ppm of the test substance to groups of 50 f344 rats of either sex for 103 weeks. similar groups of 50 b6c3f1 mice received diets containing 2,500 or 5,000 ppm of the test substance for 103 weeks groups of 50 untreated rats and mice of each sex served as controls under the conditions of this bioassay, d.i. disperse yellow 3 was considered carcinogenic for male f344 rats, causing an increased incidence of neoplastic nodules of the liver; this dye was not carcinogenic for female f344 rats. in addition, the stomach tumors found in the male rats may have been induced by the administration of the test chemical. c.i. disperse yellow 3 was carcinogenic for female b6c3f1 mice, as evidenced by the increased incidence of hepatocellular adenomas; c.i. disperse yellow 3 was not carcinogenic for male b6c3f1 mice. also, the increased incidence of malignant lymphoma in female mice may have been associated with the administration of c.i. disperse yellow 3