섬유

clincial study of urokinase-bound fibrocollagenous tubes

  • 출판일1999.03
  • 저자
  • 서지사항
  • 등록일 2016.11.02
  • 조회수 271
dacron-reinforced fibrocollagenous tubes (fct) were synthesized from canine mongrels using the mandril-rod technique in order to develop a small diameter (i. e. , 4 mm i. d. ) vascular graft. they were rendered fibrinolytic by immobilizing urokinase on to the inner surface of the tubes. urokinase-bound fibrocollagenous tubes (uk-fct), control fcts (i. e. , no bound enzyme), perloff grafts and autogeneous saphenous veins, were interposed in the carotid or femoral artery in chronic studies involving 21 canine mongrels. on the basis of doppler auscultation and palpation, the uk-fcts were statistically more patent than other candidate prostheses. a carotid arterial extracorporeal shunt was designed to evaluate acute patency results indicated a rapid thrombosis but no platlet or fibrin adherence to the graft surface was observed, as evidenced by scanning electron microscopy. (edited author abstract) 12 refs
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