섬유

radiation crosslinked hydrogels as sustained release drug delivery systems

  • 출판일1999.03
  • 저자
  • 서지사항
  • 등록일 2016.11.02
  • 조회수 240
radiation methods have been used for: modification of vascular prostheses, obtaining burn dressing materials enabling controlled drug release, the preparation of polymer ocular insert disks. the surface of polyester vascular prostheses, has been modified by deposition of acrylamide and inducing its polymerization in the solid state by $gamma$ -radiation. various burn dressings have been prepared and the most promising of all investigated turned to be composition consisting of a cotton gauze base and an active polyacrylamide hydrogel layer with addition of glycerin and immobilized provital (protein preparation). ocular insert disks made of polymer and containing pilocarpin hydrochloride which is released at controlled rate have been prepared. it has been found that high hydrophilicity and good swelling properties of the ocular insert disks made possible to incorporate pilocarpin hydrochloride into the hydrogel matrix. (edited author abstract) refs
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