섬유

Hollow fiber enzymic reactors for a two substrate process: Analytical modeling and numerical simulations

  • 출판일2000.03
  • 저자
  • 서지사항
  • 등록일 2016.11.02
  • 조회수 244
The use of immobilized enzyme reactors in biotechnology and biomedicine is rapidly expanding. This study concentrates on hollow-fiber (HF) enzymic reactors for continuous, signle-pass operation. The enzyme, in a soluble form, is physically confined within the shell section of the reactor and the substrate solution flows through the lumen section of it. We consider here a two-substrate reaction proceeding via the Ping-Pong mechanism, with substrates and reaction products diffusing through the fiber expected conversion as a function of the volumetric flow rate, kinetic constants, diffusion coefficients, geometric dimensions of the reactor, the flow regimen in the apparatus and substrates concentrations. The model equations are solved by a numerical procedure and the system performance is simulated. Depending on the operation conditions employed, the reactor is controlled by kinetic processes, diffusion processes, or both.
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