solid-state technology was used to fabricate a new type of glucose sensor and a differential measurement system was incorporated with the sensor in order to suppress interfering signals. this glucose sensor was composed of film electrodes and an enzyme-immobilizing membrane. the hydrogen peroxide electrodes were fabricated by metallic film deposition. glucose oxidase (god), an enzyme, was immobilized in photosensitive polyvinyl alcohol to enable the enzyme-immobilizing membrane to be formed by the usual photolithographic method. two anodes and one common cathode were formed on a glass substrate. one of the anodes was coated with pva containing active enzyme and the other with pva containing deactivated enzyme. by setting up a differential output measurement system, it was possible to suppress the interfering signals that might be generated by some other reducing substances in a sample solution. with this measuring technique, the signal of ascorbic or uric acids up to 100 mg/dl was successfully cancelled. glucose concentrations in the range 5 to 100 mg/dl could be detected by the present sensor