the following major discoveries are reported on herein: 1 we have established procedures for the dissociation and reassembly of ciliary membranes from olfactory epithelium under conditions that allow survival of the olfactory adenylate cyclase. these studies represent a first step toward the molecular dissection and functional reconstitution of the chemosensory membrane. 2 we have discovered that the olfactory adenylate cyclase is regulated by calcium/calmodulin and characterized the effects of calcium/calmodulin on modulation of this enzyme. 3 we have characterized proteins that are substrates for cyclic amp-dependent protein kinase in ciliary and axonal membranes of olfactory receptor cells. in addition, we have identified a protein of which the phosphorylation proceeds independent of cyclic nucleotides and is inhibited by low concentrations of calcium. 4 we have established a library of monoclonal antibodies against olfactory cilia and identified several epitopes that are unique to chemosensory cilia and absent from olfactory nerve membranes, respiratory cilia and membranes from a host of other tissues. keywords: olfaction, smell, cyclic amp, signal transduction, monoclonal antibodies. (kt)