The patterned non-woven fabric structure is a typical non-homogeneous non-woven fabric and is frequently used as a hygienic medical absorbent material to control fluid transport for directional delivery. In this paper, the characteristics of the structural variation in both strip and point patterned non-woven fabrics are examined, and the relationship between the global permeabilities in both the transverse and in-plane directions in the patterned non-woven fabrics and the local fabric structural parameters (e.g. fiber diameter, fiber orientation distribution, fabric porosity, and local pattern dimensions) is established.