[비의류제품] Effect of Diallyl Disulfide Immobilization on the Immunoreaction of Polysulfone Membranes 출판일 : 2010.07.01 저자 : Le-Shin Chang, Te-Li Su, Ming-Chien Yang, Fu-Chen Kung 서지사항 : Textile Research Journal, Volume 80, Issue 11, 1038페이지 등록일 : 2011.11.04 I 조회수 : 210 작성자 : admin |
Diallyl disulfide (DADS) was covalently bonded to a layer of poly(acrylic acid) grafting on
the surface of polysulfone (PSF) membranes. The effects of DADS bonding on oxidative
stress, removal of cholesterol, triglyceride and endotoxin, and the ability of thrombus
prevention were then evaluated. The surface was characterized with contact angle
measurement and Fourier transform infrared spectrometer. Thrombus, platelet aggregation,
and oxidative stress were evaluated using human blood. Coagulation times (CT) were
evaluated in vitro for hemocompatibility. The production of reactive oxygen species was
measured by the chemiluminescence (CL) method to evaluate the oxidative stress.
Furthermore, the removal of cholesterol, triglyceride and bacterial endotoxin by DADS-
bonding PSF was measured with enzyme-linked immunosorbent assay. The results showed
that the DADS-bonding PSF membrane exhibited longer CT, and less adsorption of plasma
proteins than the unmodified PSF membrane. In addition, the CL counts of hydrogen
peroxide and superoxide values for the DADS-bonding PSF membrane were more stable
than those for the unmodified PSF membrane. In addition, the DADS-bonding PSF membrane
exhibited ability to remove cholesterol, triglyceride and endotoxin. These results
demonstrate that DADS bonding can improve the blood compatibility of PSF membranes. The
DADS-bonding PSF membrane could offer protection for patients against oxidative stress
and could also reduce the dosage of anticoagulant required during hemodialysis.
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