In this study, the commercially available cosmetic textile agent containing aloe vera for skin caring benefits was used for the development of cosmetic textiles. The empirical characterization model comprising three major categories, namely (1) material characterization and ingredient identification, (2) fabric performance testing, and (3) biological safety and biological response to human skin, was established to characterize the cosmetic textile agent and the developed cosmetic textiles. This systematic characterization model is expected to provide a guideline for commercial sectors and researchers to identify and evaluate the performance of cosmetic textile agents and cosmetic textiles in a safety and objective manner.